COMPARATIVE STUDY ON THE EFFECT OF TETRACYCLINE AND TETRAOLEANE ON CULTIVATED HUMAN LYMPHOCYTES

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A Dynamic Programming Solution to Bounded Dejittering Problems

We propose a dynamic programming solution to image dejittering problems with bounded displacements and obtain efficient algorithms for the removal of line jitter, line pixel jitter, and pixel jitter.Comment: The final publication is available at link.springer.co

Options for reducing oxidative toxicity of l-dopa by combination with synthetic or natural radical protectors

Parkinson disease (PD) is a multifactorial disease that is not well-established. It takes a leading place among contemporary frequent diseases of the central nervous system (CNS). The levodopa (L-dopa) clinical effect is diminished by motor complications resulting from prolonged treatment. Due to the L-dopa neurotoxic effect in the disease treatment, the L-dopa administration is delayed as long as possible in order to avoid side effects. In addition, combining L-dopa therapy with antioxidants (from natural or synthetic origin), may decrease side-effects and provide symptomatic relief. The aim of the current research is through experimental model of healthy mice to explore the possibility to reduce the oxidative stress (OS) induced by the L-dopa drug after its combining with: an essential oil isolated from Rosa damascena Mill., the vitamin C and synthetic antioxidant 1-ethyl-3- [4- (2,2,6,6-tetramethylpiperidine-1-oxyl)] - 1-nitrosourea SLENU. The antioxidants protective effects against the L-dopa oxidative toxicity were evaluated through the oxidative stress indicators - the lipid and protein oxidation end products – measured as MDA, protein carbonyl content, and advanced glycation end products (AGEs) in blood plasma of experimental mice

Detection of corn and sunflower oil adulterations of olive oils using fluorescence spectroscopy

A novel approach for the detection of admixtures of vegetable (corn and sunflower) oils in commercially available olive oils on a qualitative level is presented. Chemical analysis of the contents of fatty acids in each of the model systems under study is performed. The dependence of the ratio of the two main fluorescence intensity peaks 1 2 F / F and that of the linoleic to oleic acids C18:2 / C18:1 is studied. It is shown that an increase of the concentration of the adulterant the maximum of the first fluorescence peak exhibits a wavelength shift. Fluorescence analysis can be used for a qualitative real time determination of the presence of adulterants in olive oil by comparison of the observed particular fluorescence spectrum with those from a database of spectra of olive oils and adulterants from a particular region

Anesthetic considerations for microlaryngeal surgery

Introduction: Microlaryngeal surgery encompasses a wide range of laryngeal procedures. Patients presenting for microlaryngeal surgery frequently have a difficult airway. The chosen approach to this airway depends on the pathology and the patient’s symptoms. The Aim of the study is to determine the risk factors and anesthetic problems during microlaryngeal surgery.Materials and Methods: A prospective cohort study including 100 patients undergoing microlaryngeal surgery in the Department of Otorhinolaryngology at the University Hospital „Queen Giovanna“ – ISUL, Sofia, in the period 2020–2021; Medical University-Sofia. Preoperative examination of the larynx is performed in all patients by Storz 8402 ZX fiber optic laryngoscope with video capability.Results and discussion: In 69% of the patients the tumor mass causing obstruction is localized in the area of the larynx, and in 31% of them the tumor mass is localized in the area of the hypopharynx. From the patients with tumor mass causing laryngeal obstruction 42% are with 1st degree of obstruction, 29% are with 2nd degree, 27% are with 3rd degree and 2% are with respiratory failure at rest. Twenty six percent (26%) of the patients had pulse rate<45 beats per minute during putting on the tube of Kleinsasser. This is very dangerous reflex reaction of the heart, which we believe is caused by parasympathetic nervous system. The rate of difficult endotracheal intubation among patients presenting for microlaryngeal surgery is higher than among the general surgical patient population. Difficulties during endotracheal intubation in our study are due to higher percent of laryngeal obstruction and pharyngeal restriction because of the intraoral masses.Conclusion: Anesthesia for microlaryngeal surgery has always been demanding, as often pathology interferes with the anesthesiologist’s field of work

Disparity and optical flow partitioning using extended Potts priors

This paper addresses the problems of disparity and optical flow partitioning based on the brightness invariance assumption. We investigate new variational approaches to these problems with Potts priors and possibly box constraints. For the optical flow partitioning, our model includes vector-valued data and an adapted Potts regularizer. Using the notion of asymptotically level stable (als) functions, we prove the existence of global minimizers of our functionals. We propose a modified alternating direction method of multipliers. This iterative algorithm requires the computation of global minimizers of classical univariate Potts problems which can be done efficiently by dynamic programming. We prove that the algorithm converges both for the constrained and unconstrained problems. Numerical examples demonstrate the very good performance of our partitioning method

FibroTest, transient elastography method, and combined FibroTest and transient elastography method for diagnosis of severe hepatic fibrosis and cirrhosis in adults with chronic hepatitis C

This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the diagnostic accuracy of FibroTest, transient elastography method, combined FibroTest and transient elastography method, no matter the sequence, using liver biopsy as reference standard, for assessment of severe hepatic fibrosis and cirrhosis in adults with chronic hepatitis C without any co-infections such as hepatitis B, HIV, and alcoholic liver disease. To compare the accuracy of FibroTest, transient elastography method, combined FibroTest and transient elastography method, for assessment of hepatic fibrosis in adults with chronic hepatitis C. To explore heterogeneity analysing the following study factors: different grade of inflammation according to the liver biopsy; different lengths of liver biopsy sample; different number of portal tracts included in a liver biopsy sample; different serum levels of ALT activity. different grade of inflammation according to the liver biopsy; different lengths of liver biopsy sample; different number of portal tracts included in a liver biopsy sample; different serum levels of ALT activity

Glucocorticosteroids for people with alcoholic hepatitis

This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the benefits and harms of glucocorticosteroids in people with alcoholic hepatitis

A Comparative Study of Outranking Methods for Multi-Criteria Optimization of Electromechanical Modules

The paper presents a comparative assessment of the procedures for applying two outranking methods in solving multi-criteria optimization tasks. The conducted study compares the fundamental PROMETHEE (Preference Ranking Organization METHod for Enrichment Evaluations) method, which is widely proposed to support selection of the best compromise alternative in multi-criteria tasks, with the newly developed RAZOR (Ranking of Alternatives by Z-score Operation Ratings) method. The paper describes the ranking methods and provides demonstrative numerical examples for existing electromechanical modules. The results of the numerical examples from the conducted multi-criteria optimization on a number of given criteria are presented. The study demonstrated that the calculation procedure in PROMETHEE method demands certain level of preliminary knowledge, but provides fine setting of preferences by the decision-maker. The RAZOR method, on the other hand, demands no preliminary knowledge and it is easier to visualize graphically